Manhattan Guidebook - Alphabet City - Avenue B and East 8th Street Alphabet City is a neighborhood located within the Lower East Side and East Village in the New York City borough of Manhattan. It is also known as Loisaida, a Spanglish adaptation of ‘Lower East Side’. Its name comes from Avenues A, B, C, and D, the only avenues in Manhattan to have single-letter names. It is bordered by Houston...